Scientific reports · 2018
Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Yagi Minami, Tanaka Atsushi, Abe Masanori, Namisaki Tadashi, Yoshiji Hitoshi, Takahashi Atsushi, Ohira Hiromasa, Komori Atsumasa, Yamagiwa Satoshi, Kikuchi Kentaro, Yasunaka Tetsuya, Takaki Akinobu, Ueno Yoshiyuki, Honda Akira, Matsuzaki Yasushi, Takikawa Hajime
Аннотация
Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japanese PBC patients. We performed a multicenter, observational, cross-sectional study. The PBC-40 and the short form (SF)-36 were used as measures of symptoms and HRQOL. Four-hundred-ninety-six patients with PBC were enrolled. In the PBC-40, the average score was highest in the emotional domain, followed by the fatigue domain. The HRQOL measured using SF-36 was also impaired, especially in the physical and role-social components. After adjustments of variables, female sex, younger age at diagnosis, and lower serum albumin level were independently associated with fatigue scores, while a longer follow-up period and lower serum albumin levels were associated with itch scores.