Retinal optical coherence tomography angiography findings in the new- onset migraine patients: a prospective case-control study.

PURPOSE: the purpose of this study is to evaluate both macular thickness and vascular density in patients with new- onset migraine using optical coherence tomography angiography (OCTA).

METHODS

This prospective case-control study included 109 participants divided into two groups: Group (A), which comprised patients with New- onset migraine (n=54) and group (B), which included healthy control group (n= 55). Both groups were evaluated ophthalmologically and imaged by optical coherence tomography angiography (OCTA) to evaluate both retinal thickness and vasculature.

RESULTS

Both groups were well matched regarding age, sex, best corrected visual acuity (BCVA), axial length, spherical equivalent (SER) and intraocular pressure (IOP), with no significant difference. The migraine group demonstrated a significant decrease in all vascular parameters in comparison with control group p-value is significant (p < 0.05), Furthermore, when comparing migraine patients with aura to those without aura; patients with aura were significantly more affected.

CONCLUSION

Patients with migraine, even at their first diagnosis, exhibit abnormal retinal microvasculature. Furthermore, those with aura demonstrate a higher susceptibility to retinal vascular involvement.

CLINICAL TRIAL NUMBER: Not applicable.