Rate of Participation in a Second Randomized Clinical Trial and Factors Associated with the Likelihood of Participation among IBD Patients who already Experienced a Randomized Clinical Trial.

BACKGROUND

To investigate the rate of participation in a second trial among inflammatory bowel disease (IBD) patients and to identify factors influencing their likelihood of re-engagement.

METHODS

Retrospective, single-center study. Multivariate logistic regression was used to identify factors associated with re-participation.

RESULTS

A total of 29.0% participated in a second trial. In ulcerative colitis, distance >100 km from the clinic and steroid use before the first trial were associated with reduced re-participation. In Crohn's disease (CD), long-standing disease and reimbursement during the first trial were associated with increased re-participation; previous CD-related surgery was associated with reduced re-participation.

CONCLUSIONS

Understanding factors affecting re-participation in IBD trials is crucial to improving patient involvement in research.