Study of lipid status in the euglycemic offsprings of diabetic parents with sex, age matched controls among South Indian population.

CONTEXT: Metabolic syndrome has a silent but a fatal course. So, if we are able to identify the subjects in the early course of the disease then we will be able to prevent them from fatal complications later.

AIM: To study the lipid status among euglycemic offspring of diabetic parents by appropriately matching for sex, and age in controls.

DESIGN

It is a case control study involving 52 subjects and 25 controls done in a tertiary care center in Chennai.

METHODS AND MATERIALS: Using inclusion and exclusion criteria 52 euglycemic offspring as subjects and 25 controls were taken. Serum high density lipoprotein (HDL), serum triglycerides, blood pressure and waist circumference we obtained. The results were tabulated and studied.

STATISTICAL ANALYSIS: Student t test was employed.

RESULTS

Siblings of diabetic parents had lower levels of serum HDL. Odds ratio showed that offspring's of diabetic parents had the odds of having low HDL 4.67 times when compared to the controls with a confidence interval of 1.6001-13.6563, P value of 0.0048. The other parameters did not show any gross variation. Siblings of diabetic fathers had a more deranged profile than the siblings of diabetic mothers.

CONCLUSION

There is significant association between parental diabetic status and dyslipidemia. If they are detected early then progress to complications can be delayed.