bioRxiv : the preprint server for biology · 2023
Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology.
ПрепринтСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hills Rory A, Kit Tan Tiong, Cohen Alexander A, Keeffe Jennifer R, Keeble Anthony H, Gnanapragasam Priyanthi N P, Storm Kaya N, Hill Michelle L, Liu Sai, Gilbert-Jaramillo Javier, Afzal Madeeha, Napier Amy, James William S, Bjorkman Pamela J, Townsend Alain R, Howarth Mark
Аннотация
Defending against future pandemics may require vaccine platforms that protect across a range of related pathogens. The presentation of multiple receptor-binding domains (RBDs) from evolutionarily-related viruses on a nanoparticle scaffold elicits a strong antibody response to conserved regions. Here we produce quartets of tandemly-linked RBDs from SARS-like betacoronaviruses coupled to the mi3 nanocage through a SpyTag/SpyCatcher spontaneous reaction. These Quartet Nanocages induce a high level of neutralizing antibodies against several different coronaviruses, including against viruses not represented on the vaccine. In animals primed with SARS-CoV-2 Spike, boost immunizations with Quartet Nanocages increased the strength and breadth of an otherwise narrow immune response. Quartet Nanocages are a strategy with potential to confer heterotypic protection against emergent zoonotic coronavirus pathogens and facilitate proactive pandemic protection.