Expanding PPMI through Remote Data Acquisition and Analysis: Early Success and Future Growth with myPPMI.

The creation and ongoing development of the myPPMI platform (see Stanley et al in this issue), has enabled the Parkinson's Progression Markers Initiative (PPMI) to expand our research efforts to acquire additional data, engage a large number of participants, and reduce participant burden to enable long-term follow-up. We now review specific virtual and remote studies and sub-studies including Found, PPMI Online, and PPMI Cognitive that PPMI has developed to enhance participant engagement and enable remote data collection. FOUND in PPMI was initiated before myPPMI and continues to serve as a model for remote participant engagement. FOUND maintains longitudinal contact, reducing study attrition, and preserving data continuity. PPMI Online, now part of myPPMI, enables low-burden, participant-reported data collection, reduces geographic barriers, and enables sub-studies of less common subgroups. Cognitive testing is another study within myPPMI to assess longitudinal cognition. myPPMI, a global web-based portal, introduces precision recruitment, real-time eligibility matching, and inclusive design. Together, these innovations enable remote and hybrid recruitment and study conduct, reduce logistical and economic barriers, and advance scalable, participant-centered research to transform the landscape of Parkinson's disease studies across populations. ANN NEUROL 2026.