Archives of pharmacal research · 2026
Modulation of mitochondrial DNA copy number: therapeutic potential of phytochemicals and plant extracts-a comprehensive review.
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Perri Maria Rosaria, Cerantonio Annamaria, Cipriani Maria Grazia, Manna Ida, Aureli Anna, Marziani Beatrice, Andreozzi Francesco, Mannino Gaia Chiara, Mancuso Elettra, Averta Carolina, Statti Giancarlo, Citrigno Luigi, Mainieri Davide
Аннотация
Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative diseases. Recent studies have revealed that various plant-derived extracts, as well as the secondary metabolites they produce, known as phytochemicals, can modulate mtDNA-CN through mechanisms including the regulation of mitochondrial biogenesis, oxidative stress, and mtDNA repair. This review examines plant-derived extracts and phytochemical compounds from a wide range of plant species- including Ginkgo biloba, Crocus sativus, Curcumin and many others- able to modulate mtDNA dynamics, scavenging oxygen free radicals and improving antioxidant defense systems.