Future microbiology · 2018
Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.
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Esposito Emanuela, Campolo Michela, Casili Giovanna, Lanza Marika, Filippone Alessia, Peritore Alessio F, Cuzzocrea Salvatore
Аннотация
AIM: The objective of this research was to evaluate the antifungal properties of the association between grape seed and pea by using a nonpharmacological medical device that contains them.
MATERIALS & METHODS: A murine model of vulvovaginal candidiasis, induced by Candida albicans infection, was used.
RESULTS: We showed that topical treatment with the device significantly reduced the fungal burden in vagina and preserved vagina tissue architecture from C. albicans infection.
CONCLUSION: We can support the potential beneficial effect of the association between grape and pea extract present in the medical device. Together these results supported this device as a favorable antifungal agent and a promising synergist with fluconazole in the clinical management of vulvovaginal candidiasis caused by C. albicans biofilms.
MATERIALS & METHODS: A murine model of vulvovaginal candidiasis, induced by Candida albicans infection, was used.
RESULTS: We showed that topical treatment with the device significantly reduced the fungal burden in vagina and preserved vagina tissue architecture from C. albicans infection.
CONCLUSION: We can support the potential beneficial effect of the association between grape and pea extract present in the medical device. Together these results supported this device as a favorable antifungal agent and a promising synergist with fluconazole in the clinical management of vulvovaginal candidiasis caused by C. albicans biofilms.