Zhonghua nei ke za zhi · 2002
Myocardial matrix metalloproteinase-3 and matrix metalloproteinase inhibitor-1 expression in congestive heart failure.
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Wang Xianmei, Yang Lixia, Qi Feng, Et Al
Аннотация
OBJECTIVE: To study the changes of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1(TIMP-1) expression during congestive heart failure.
METHODS: Using the reverse transcriptase-polymerase chain reaction(RT-PCR) assay, we detected MMP-3 and TIMP-1 expression in 31 patients with rheumatic heart disease (RHD) and 8 health subjects. Cardiac function parameters were measured with echocardiographs.
RESULTS: Pathological changes of myocardial tissure in CHF with valvular heart disease showed typical myocardial remodeling. As compared with the control group, the contents of MMP-3 in RHD patients were increased significantly ( P < 0.01). The worse the cardiac function, the higher the contents of MMP-3. TIMP-1 expressions showed a reverse correlation.
CONCLUSIONS: It is suggested that the altered expression of MMP-3 and TIMP-1 contributes to myocardial remodeling and might lead to the development and progression of congestive heart failure. These changes may induce a direct effect on the progressive deterioration of cardiac function.
METHODS: Using the reverse transcriptase-polymerase chain reaction(RT-PCR) assay, we detected MMP-3 and TIMP-1 expression in 31 patients with rheumatic heart disease (RHD) and 8 health subjects. Cardiac function parameters were measured with echocardiographs.
RESULTS: Pathological changes of myocardial tissure in CHF with valvular heart disease showed typical myocardial remodeling. As compared with the control group, the contents of MMP-3 in RHD patients were increased significantly ( P < 0.01). The worse the cardiac function, the higher the contents of MMP-3. TIMP-1 expressions showed a reverse correlation.
CONCLUSIONS: It is suggested that the altered expression of MMP-3 and TIMP-1 contributes to myocardial remodeling and might lead to the development and progression of congestive heart failure. These changes may induce a direct effect on the progressive deterioration of cardiac function.