Comparative evaluation of topical and intramuscular coenzyme Q10 application in non-surgical periodontal disease management: A randomized clinical study.

Periodontal disease remains challenging to manage because adjunctive antioxidant therapies are not well standardized forroute of administration or dosing relative to scaling and root planing (SRP). Therefore, it is of interest to evaluate SRP alone, SRP plus topical CoQ10 and SRP plus intrasulcular CoQ10 at 150 sites in 50 patients with chronic periodontitis over 4 weeks. Plaque Index, Gingival Index, Modified Sulcular Bleeding Index and Probing Pocket Depth were assessed at baseline and follow up in all three groups. All groups showed significant improvement, but Group 3 (intrasulcular CoQ10 + SRP) demonstrated the greatest reduction in probing pocket depth, from 6.52 ±1.07 mm to 3.67±0.28 mm (p = 0.000). Thus, intrasulcular CoQ10 + SRP is superior for periodontal regeneration opening new adjunctive antioxidant therapy pathways.