International journal of pediatric otorhinolaryngology · 2014
Chronic tympanic membrane perforation in an animal model.
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Emami Nader, Schloss Melvin D, Daniel Sam J
Аннотация
OBJECTIVE: The aim of this study was to revalidate and reproduce a chronic tympanic membrane perforation animal model.
STUDY DESIGN: Prospective, animal study.
METHODS: Eight female chinchillas underwent bilateral thermal myringotomy. The edges of the perforation were folded inward using microflaps. The perforations were followed over time to monitor the course of closure.
RESULTS: Two animals were excluded from the study because of ear infection. None of the other tympanic membrane perforations remained open. The closing time varied from 4 to 6 weeks.
CONCLUSIONS: Our findings demonstrate that the thermal myringotomy combined with infolding technique is not a reliable and consistent method to create a chronic tympanic membrane perforation. The closing time is shorter than expected and varies among the study subjects. There is a clear need for developing a reliable chronic tympanic membrane perforation model.
STUDY DESIGN: Prospective, animal study.
METHODS: Eight female chinchillas underwent bilateral thermal myringotomy. The edges of the perforation were folded inward using microflaps. The perforations were followed over time to monitor the course of closure.
RESULTS: Two animals were excluded from the study because of ear infection. None of the other tympanic membrane perforations remained open. The closing time varied from 4 to 6 weeks.
CONCLUSIONS: Our findings demonstrate that the thermal myringotomy combined with infolding technique is not a reliable and consistent method to create a chronic tympanic membrane perforation. The closing time is shorter than expected and varies among the study subjects. There is a clear need for developing a reliable chronic tympanic membrane perforation model.