ChatIOS: Improving automatic 3-dimensional tooth segmentation via GPT-4V and multimodal pre-training.

OBJECTIVES

This study aims to propose a framework that integrates GPT-4V, a recent advanced version of ChatGPT, and multimodal pre-training techniques to enhance deep learning algorithms for 3-dimensional (3D) tooth segmentation in scans produced by intraoral scanners (IOSs).

METHODS

The framework was developed on 1800 intraoral scans of approximately 24,000 annotated teeth (training set: 1200 scans, 16,004 teeth; testing set: 600 scans, 7995 teeth), from the Teeth3DS dataset, which was gathered from 900 patients with both maxillary and mandible regions. The first step of the proposed framework, ChatIOS, is to pre-process the 3D IOS data to extract 3D point clouds. Then, GPT-4V generates detailed descriptions of 2-dimensional (2D) IOS images taken from different view angles. In the multimodal pre-training, triplets, which comprise point clouds, 2D images, and text descriptions, serve as inputs. A series of ablation studies were systematically conducted to illustrate the superior design of the automatic 3D tooth segmentation system. Our quantitative evaluation criteria included segmentation quality, processing speed, and clinical applicability.

RESULTS

When tested on 600 scans, ChatIOS substantially outperformed the existing benchmarks such as PointNet++ across all metrics, including mean intersection-over-union (mIoU, from 90.3 % to 93.0 % for maxillary and from 89.2 % to 92.3 % for mandible scans), segmentation accuracy (from 97.0 % to 98.0 % for maxillary and from 96.8 % to 97.9 % for mandible scans) and dice similarity coefficient (DSC, from 98.1 % to 98.7 % for maxillary and from 97.9 % to 98.6 % for mandible scans). Our model took only approximately 2s to generate segmentation outputs per scan and exhibited acceptable consistency with clinical expert evaluations.

CONCLUSIONS

Our ChatIOS framework can increase the effectiveness and efficiency of 3D tooth segmentation that clinical procedures require, including orthodontic and prosthetic treatments. This study presents an early exploration of the applications of GPT-4V in digital dentistry and also pioneers the multimodal pre-training paradigm for 3D tooth segmentation.

CLINICAL SIGNIFICANCE: Accurate segmentation of teeth on 3D intraoral scans is critical for orthodontic and prosthetic treatments. ChatIOS can integrate GPT-4V with pre-trained vision-language models (VLMs) to gain an in-depth understanding of IOS data, which can contribute to more efficient and precise tooth segmentation systems.