Journal of gastroenterology and hepatology · 2026
Postelectroacupuncture Fecal Microbiota Transplantation (post-EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota-Bile Acid Metabolic Pathway.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Han Yong-Li, Shang Dong-Fang, Tang Juli, Yu Dong-Dong, Zhang Liang-Yu, Zhou Jing, Wang Qing-Bo
Аннотация
BACKGROUND: Electroacupuncture (EA) reshapes intestinal flora; whether post-EA fecal microbiota transplantation (post-EA FMT) regulates gastrointestinal hormones via the gut microbiota-bile acid (BA) pathway remains unclear.
METHODS: Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post-EA. Fecal microbiota from EA/SEA-treated rats were transplanted into pseudo-germ-free (PGF) rats. Gut microbiota and BA profiles were analyzed.
RESULTS: EA downregulated Ghrelin, PYY, GLP-1, upregulated CCK, and enhanced motility in FD rats. Post-EA FMT increased Firmicutes/Bacteroidetes (phylum); upregulated Lactobacillus, Prevotella, [Prevotella] (genus); decreased Blautia, Proteobacteria, Bacteroides; reduced multiple BAs (including TUDCA/TCDCA). TUDCA/TCDCA showed strong positive correlation.
CONCLUSIONS: The gut microbiota-BA pathway associates with post-EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota-BA pathway is associated with post-EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota-BA pathway is associated with post-EA FMT's beneficial regulation of gastrointestinal hormones. The Lactobacillus/TUDCA/TCDCA axis represents a candidate pathway that may contribute to this process (validation pending). Current findings indicate strong correlations, not causality.
METHODS: Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post-EA. Fecal microbiota from EA/SEA-treated rats were transplanted into pseudo-germ-free (PGF) rats. Gut microbiota and BA profiles were analyzed.
RESULTS: EA downregulated Ghrelin, PYY, GLP-1, upregulated CCK, and enhanced motility in FD rats. Post-EA FMT increased Firmicutes/Bacteroidetes (phylum); upregulated Lactobacillus, Prevotella, [Prevotella] (genus); decreased Blautia, Proteobacteria, Bacteroides; reduced multiple BAs (including TUDCA/TCDCA). TUDCA/TCDCA showed strong positive correlation.
CONCLUSIONS: The gut microbiota-BA pathway associates with post-EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota-BA pathway is associated with post-EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota-BA pathway is associated with post-EA FMT's beneficial regulation of gastrointestinal hormones. The Lactobacillus/TUDCA/TCDCA axis represents a candidate pathway that may contribute to this process (validation pending). Current findings indicate strong correlations, not causality.