European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
Anaplastic and poorly differentiated thyroid carcinomas at intervention sites: implications of track seeding and the importance of follow-up monitoring- report of two cases.
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Seok Jungirl, Kim Yoo Hyung, Won Jae-Kyung, Hwangbo Yul, Park Seog Yun, Ryu Junsun
Аннотация
INTRODUCTION: Radiofrequency ablation (RFA) is widely used to treat benign thyroid nodules. While pre-ablation cancer screenings can produce false-negatives, tumor seeding is rare, and aggressive thyroid cancers following RFA have not been reported. We present two cases of potential track seeding after RFA.
CASE REPORT: The first patient is a 56-year-old female who developed anaplastic thyroid cancer, while the second is a 61-year-old female diagnosed with poorly differentiated thyroid cancer. Both had a history of RFA for presumed benign nodules, with cancer identified at the intervention sites.
CONCLUSION: These cases highlight the need for thorough pre-treatment biopsy and careful needle handling during RFA. To date, no cases of cancer directly induced by RFA have been reported; therefore, it is likely that thyroid carcinoma coexisted at the time of the procedure or developed afterward. Early detection through regular follow-up could have prevented progression to aggressive disease. This emphasizes the importance of diligent post-procedural monitoring.
CASE REPORT: The first patient is a 56-year-old female who developed anaplastic thyroid cancer, while the second is a 61-year-old female diagnosed with poorly differentiated thyroid cancer. Both had a history of RFA for presumed benign nodules, with cancer identified at the intervention sites.
CONCLUSION: These cases highlight the need for thorough pre-treatment biopsy and careful needle handling during RFA. To date, no cases of cancer directly induced by RFA have been reported; therefore, it is likely that thyroid carcinoma coexisted at the time of the procedure or developed afterward. Early detection through regular follow-up could have prevented progression to aggressive disease. This emphasizes the importance of diligent post-procedural monitoring.