Cell host & microbe · 2023
Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Yu Jingjing, Zhu Peng, Shi Linlin, Gao Na, Li Yani, Shu Chang, Xu Ying, Yu Ying, He Junqing, Guo Dingming, Zhang Xiaoman, Wang Xiangfeng, Shao Sirui, Dong Wei, Wang Yuwei, Zhang Wei, Zhang Wanguang, Chen Wei-Hua, Chen Xiaoping, Liu Zhi, Yang Xiangliang, Zhang Bixiang
Аннотация
Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts and identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC patients with delayed recovery to mice similarly impacted recovery time post hepatectomy. However, oral gavage of B. longum improved liver function and repair in these mice. In a clinical trial of HCC patients, orally administering a probiotic bacteria cocktail containing B. longum reduced the rates of delayed recovery, shortened hospital stays, and improved overall 1-year survival. These benefits, attributed to diminished liver inflammation, reduced liver fibrosis, and hepatocyte proliferation, were associated with changes in key metabolic pathways, including 5-hydroxytryptamine, secondary bile acids, and short-chain fatty acids. Our findings propose that gut microbiota modulation can enhance LFR, thereby improving postoperative outcomes for HCC patients.