Presse medicale (Paris, France : 1983) · 1998
[Iatrogenic acute renal failure caused by overdosage of flecainide acetate].
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Meurin P, Larrazet F, Weber H, Bourmayan C
Аннотация
BACKGROUND: Rapid degradation of renal function may occur in patients given drug regimens combining a converting enzyme inhibitor, a diuretic and a nonsteroidal anti-inflammatory drug.
CASE REPORT: A patient given flecainide and an enalapril /hydrochlorothiazide combination in a well-tolerated long-term regimen suddenly developed acute renal failure when a nonsteroidal anti-inflammatory drug was introduced leading to an overdose of the anti-arrhythmic drug.
DISCUSSION: A poor understanding of the elimination routes for anti-arrhythmic drugs and the risks involved when combined with nonsteroidal anti-inflammatory drugs modifying glomerular hemodynamics can lead to dangerous prescriptions and life-threatening situations in patients on multiple drug regimens.
CASE REPORT: A patient given flecainide and an enalapril /hydrochlorothiazide combination in a well-tolerated long-term regimen suddenly developed acute renal failure when a nonsteroidal anti-inflammatory drug was introduced leading to an overdose of the anti-arrhythmic drug.
DISCUSSION: A poor understanding of the elimination routes for anti-arrhythmic drugs and the risks involved when combined with nonsteroidal anti-inflammatory drugs modifying glomerular hemodynamics can lead to dangerous prescriptions and life-threatening situations in patients on multiple drug regimens.
Предметные рубрики MeSH
Acute Kidney InjuryAgedAngiotensin-Converting Enzyme InhibitorsAnti-Arrhythmia AgentsAnti-Inflammatory Agents, Non-SteroidalAntihypertensive AgentsAtrial FibrillationDiureticsDrug InteractionsDrug Therapy, CombinationElectrocardiographyEnalaprilFlecainideHeart BlockHumansHydrochlorothiazideHypertensionIatrogenic DiseaseIndomethacinMalePeriarthritisSodium Chloride Symporter Inhibitors