Acta cardiologica · 2005
Herpesvirus DNA (Epstein-Barr virus, herpes simplex virus, cytomegalovirus) in circulating monocytes of patients with coronary artery disease.
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Schlitt Axel, Blankenberg Stefan, Weise Kerstin, Gärtner Barbara C, Mehrer Torsten, Peetz Dirk, Meyer Juergen, Darius Harald, Rupprecht Hans J
Аннотация
BACKGROUND: The underlying mechanism of the chronic inflammatory process in atherosclerosis is still unknown. As a possible trigger, several studies in recent years have suggested that different viruses and bacteria are associated with atherosclerotic diseases.
METHODS: We applied polymerase chain reaction to analyse whether Epstein-Barr virus (EBV), herpes simplex virus (HSV), and cytomegalovirus (CMV) DNA could be detected in CD14 + cells from 184 patients with angiographically documented coronary artery disease (CAD) (74 patients with stable angina (SAP), 51 patients with unstable angina (UAP), and 59 patients with myocardial infarction (MI)) and from 52 healthy controls.
RESULTS: In two patients (one patient with SAP, one patient with UAP) with CAD and one healthy control, DNA from CMV was found (p = 0.469). HSV DNA was detected in one patient (SAP) but not in any controls (p = 0.644). EBV DNA was found in nine patients (three patients with SAP, one patient with UAP, five patients with MI), and two controls (p = 0.752).
CONCLUSION: Our data do not support the hypothesis that herpesvirus-infected monocytes are related to the incidence of human coronary atherosclerosis.
METHODS: We applied polymerase chain reaction to analyse whether Epstein-Barr virus (EBV), herpes simplex virus (HSV), and cytomegalovirus (CMV) DNA could be detected in CD14 + cells from 184 patients with angiographically documented coronary artery disease (CAD) (74 patients with stable angina (SAP), 51 patients with unstable angina (UAP), and 59 patients with myocardial infarction (MI)) and from 52 healthy controls.
RESULTS: In two patients (one patient with SAP, one patient with UAP) with CAD and one healthy control, DNA from CMV was found (p = 0.469). HSV DNA was detected in one patient (SAP) but not in any controls (p = 0.644). EBV DNA was found in nine patients (three patients with SAP, one patient with UAP, five patients with MI), and two controls (p = 0.752).
CONCLUSION: Our data do not support the hypothesis that herpesvirus-infected monocytes are related to the incidence of human coronary atherosclerosis.
Предметные рубрики MeSH
Age FactorsAgedAnalysis of VarianceAngina PectorisAngina, UnstableBase SequenceCase-Control StudiesCoronary Artery DiseaseCytomegalovirusDNA, ViralFemaleHerpesvirus 4, HumanHumansIncidenceMaleMiddle AgedMolecular Sequence DataPolymerase Chain ReactionProbabilityPrognosisRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsSimplexvirus