Qualitative troponin I estimation in the diagnosis of acute coronary syndromes in three rural hospitals.

OBJECTIVE

To examine the utility of point-of-care qualitative troponin I (TnI) testing in patients with possible acute coronary syndromes (ACS).

METHODS

A retrospective chart review of all patients undergoing qualitative TnI testing between September 2001 and February 2002 was conducted at the emergency departments of 3 rural hospitals in Alberta. We looked at the incidence of ACS, the comparison between TnI and creatine kinase (CK) testing and the timing of testing.

RESULTS

Of the 235 patients tested, 8 had ST-elevation myocardial infarctions and 11 non ST-elevation infarctions. One patient had unstable angina with minimal myocardial damage. Qualitative TnI testing was positive in all 14 cases of infarction tested more than 6 hours after symptom onset, and CK elevation occurred in 15/17 cases (TnI sensitivity 1.0 [95% confidence interval (CI) 0.78-1.0], CK sensitivity 0.882 [95% CI 0.66-0.97]). There were 3 positive TnI tests and 33 raised CK levels in patients without evidence for ACS (TnI specificity 0.986 [95% CI 0.96-0.99], likelihood ratio [LR] 72.0 [95% CI 23.4-221.5]); CK specificity 0.847 [95% CI 0.79-0.89], LR 5.8 [95% CI 4.0-8.3]). In 44 patients (20.8%) TnI testing was inappropriately not repeated more than 6 hours after symptom onset.

CONCLUSION

Qualitative TnI testing appears highly sensitive and more specific than CK estimation in detecting myocardial infarction. Diagnostic algorithms must emphasize the importance of testing 6 or more hours after symptom onset.