American journal of dentistry · 2026
Locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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Zarei Roza, Vatankhah Pooya, Chaparzade Saman, Ebrahimirad Farbod, Hassani Pardis, Khamisi Nima, Dehzadeh Sahar, Sezavar Zahra, Deravi Niloofar, Jahangiri Sharare, Fakhimi Resaei Haleh, Khashayer Jafari Amir, Mokhtari Sakhvidi Alireza
Аннотация
PURPOSE: This systematic review and meta-analysis evaluated the effectiveness of locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis.
METHODS: A thorough literature review was performed utilizing PubMed, Scopus, Google Scholar, and ClinicalTrials.gov for studies published until June 2025. Titles, abstracts, and full texts of the eligible studies were obtained and reviewed. Data were subsequently extracted from the chosen studies and analyzed accordingly.
RESULTS: A total of 30 RCT studies with 1,211 participants were included. Our study showed that the local delivery of simvastatin and rosuvastatin significantly improved pocket depth [Weighted Mean Difference (WMD) 95% confidence interval (CI)] = -0.83, -1.31 respectively, P< 0.001), clinical attachment level (-1.20, -1.59, P< 0.001), gingival index (-0.60, -1.42, P< 0.001), modified sulcus bleeding index (-0.61, -0.36, P< 0.001), plaque index (-0.38, P< 0.001), and relative attachment level (-0.54, -0.89, P< 0.001). However, there was no significant association between the plaque index and the use of rosuvastatin (-0.20, P< 0.05).
CLINICAL SIGNIFICANCE: The local delivery of simvastatin and rosuvastatin along with scaling and root planing significantly reduced pocket depth and improved clinical attachment level, gingival index, modified sulcus bleeding index, and relative attachment level. Further clinical trials are still required to support the results of the current meta-analysis.
METHODS: A thorough literature review was performed utilizing PubMed, Scopus, Google Scholar, and ClinicalTrials.gov for studies published until June 2025. Titles, abstracts, and full texts of the eligible studies were obtained and reviewed. Data were subsequently extracted from the chosen studies and analyzed accordingly.
RESULTS: A total of 30 RCT studies with 1,211 participants were included. Our study showed that the local delivery of simvastatin and rosuvastatin significantly improved pocket depth [Weighted Mean Difference (WMD) 95% confidence interval (CI)] = -0.83, -1.31 respectively, P< 0.001), clinical attachment level (-1.20, -1.59, P< 0.001), gingival index (-0.60, -1.42, P< 0.001), modified sulcus bleeding index (-0.61, -0.36, P< 0.001), plaque index (-0.38, P< 0.001), and relative attachment level (-0.54, -0.89, P< 0.001). However, there was no significant association between the plaque index and the use of rosuvastatin (-0.20, P< 0.05).
CLINICAL SIGNIFICANCE: The local delivery of simvastatin and rosuvastatin along with scaling and root planing significantly reduced pocket depth and improved clinical attachment level, gingival index, modified sulcus bleeding index, and relative attachment level. Further clinical trials are still required to support the results of the current meta-analysis.