Locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis: A systematic review and meta-analysis.

PURPOSE: This systematic review and meta-analysis evaluated the effectiveness of locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis.

METHODS

A thorough literature review was performed utilizing PubMed, Scopus, Google Scholar, and ClinicalTrials.gov for studies published until June 2025. Titles, abstracts, and full texts of the eligible studies were obtained and reviewed. Data were subsequently extracted from the chosen studies and analyzed accordingly.

RESULTS

A total of 30 RCT studies with 1,211 participants were included. Our study showed that the local delivery of simvastatin and rosuvastatin significantly improved pocket depth [Weighted Mean Difference (WMD) 95% confidence interval (CI)] = -0.83, -1.31 respectively, P< 0.001), clinical attachment level (-1.20, -1.59, P< 0.001), gingival index (-0.60, -1.42, P< 0.001), modified sulcus bleeding index (-0.61, -0.36, P< 0.001), plaque index (-0.38, P< 0.001), and relative attachment level (-0.54, -0.89, P< 0.001). However, there was no significant association between the plaque index and the use of rosuvastatin (-0.20, P< 0.05).

CLINICAL SIGNIFICANCE: The local delivery of simvastatin and rosuvastatin along with scaling and root planing significantly reduced pocket depth and improved clinical attachment level, gingival index, modified sulcus bleeding index, and relative attachment level. Further clinical trials are still required to support the results of the current meta-analysis.