Медицинская библиотека · Parkinsonism & related disorders · 2025

Sex differences in the diagnosis latency of Parkinson's disease in Latin America.

Ramchandra Janvi, Inca-Martinez Miguel, Leal Thiago Peixoto, Chaparro-Solano Henry Mauricio, Salim Amira, Gatto Emilia M, Rojas Natalia González, Da Prat Gustavo, Micheli Federico, Santos-Lobato Bruno Lopes, Cardoso Francisco E C, Camargos Sarah, Letro Grace H, Braga-Neto Pedro, Peixoto Vitória Maria Torres, Schuh Artur F S, Tumas Vitor, Brito Manuelina M, Borges Vanderci, Candeias da Silva Carolina, Ferraz Henrique B, Chana-Cuevas Pedro, Saffie-Awad Paula, Olguin Patricio, Colombo Alicia, de la Cerda Andres, Farías Gonzalo A, Nuñez Juan Cristobal, Arboleda Gonzalo, Arboleda Humberto, Fernandez William, Arboleda-Bustos Carlos E, Orozco Jorge L, Muñoz-Ospina Beatriz, Velez-Pardo Carlos, Jiménez-Del-Río Marlene, Lopera Francisco, Moreno Sonia, Pineda David A, Buritica Omar, Torrealba-Acosta Gabriel, Medina Escobar Alex, Rodríguez-Violante Mayela, Hernández-Medrano Ana Jimena, Martinez-Ramirez Daniel, González-González Mirna, Rentería Miguel E, Alcauter Sarael, Reyes-Pérez Paula, Medina-Rivera Alejandra, Vazquez-Guevara Damaris, de María Ugalde-Mejía Lucero, Valadez M Maritza J, Cárdenas-Sáenz Omar, Rodríguez-Leyva Ildefonso, Guerra-Galicia Carlos M, Gandarilla-Martínez Nadia A, Matuk-Pérez Yamil, Morelos-Figaredo Eugenia, Salinas-Barboza Karla, Isais-Millán Sara, Pérez-Torres Teresa, Deras Gaucin Diana C, Ruiz-Contreras Alejandra E, Estrada-Bellmann Ingrid, Rios-Pinto Julia, Cornejo-Olivas Mario, Cosentino Carlos, Torres Ramirez Luis, Mori Nicanor, Mejía-Rojas Koni, Medina Ángel César, Cornejo-Herrera Iván, Ochoa Edward M, Viñuela Ángel, Dieguez Elena, Amorín Ignacio, Lescano Andrés, Mata Ignacio F

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Аннотация

BACKGROUND

Age and sex are known risk factors for Parkinson's Disease (PD), but it remains controversial if there are sex differences in the diagnosis latency. The objective of this study was to examine these sex differences in Latin America.

METHODS

The Latin American Research Consortium on the Genetics of PD (LARGE-PD) includes PD patients from countries across Latin America who were diagnosed using the UK Brain Bank criteria. Ages at onset (AAO; N = 2,792), diagnosis (AAD; N = 1,416), and calculated diagnosis latency (N = 1,416) were extracted from the LARGE-PD database and compared for both males and females overall, by country, and decade-long age ranges. A cohort was created based on available data for motor sign at onset (N = 492). Regressions examining diagnosis latency as a factor of sex, country, and motor subtype were performed. Two-tailed t-tests at 95 % confidence intervals were used to identify differences in mean AAOs, AADs, and diagnosis latencies between the sexes.

RESULTS

Across the LARGE-PD cohort, lower AAD was observed in males. Per country, AAO was lower for males in Mexico and diagnosis latency was shorter for males in Chile. Overall, younger females (≤39) and older males (≥70) are likely to experience longer latencies.

CONCLUSIONS

Our results suggest that there may be country and age dependent sex differences in AAO, AAD, and diagnosis latency of PD in Latin America. Interestingly, the mean AAO of LARGE-PD is approximately 6 years younger than studies done with European populations. Analyses with additional data are needed to determine the influence of other factors.

Для цитирования: Ramchandra Janvi, Inca-Martinez Miguel, Leal Thiago Peixoto, Chaparro-Solano Henry Mauricio, Salim Amira, Gatto Emilia M, Rojas Natalia González, Da Prat Gustavo, Micheli Federico, Santos-Lobato Bruno Lopes, Cardoso Francisco E C, Camargos Sarah, Letro Grace H, Braga-Neto Pedro, Peixoto Vitória Maria Torres, Schuh Artur F S, Tumas Vitor, Brito Manuelina M, Borges Vanderci, Candeias da Silva Carolina, Ferraz Henrique B, Chana-Cuevas Pedro, Saffie-Awad Paula, Olguin Patricio, Colombo Alicia, de la Cerda Andres, Farías Gonzalo A, Nuñez Juan Cristobal, Arboleda Gonzalo, Arboleda Humberto, Fernandez William, Arboleda-Bustos Carlos E, Orozco Jorge L, Muñoz-Ospina Beatriz, Velez-Pardo Carlos, Jiménez-Del-Río Marlene, Lopera Francisco, Moreno Sonia, Pineda David A, Buritica Omar, Torrealba-Acosta Gabriel, Medina Escobar Alex, Rodríguez-Violante Mayela, Hernández-Medrano Ana Jimena, Martinez-Ramirez Daniel, González-González Mirna, Rentería Miguel E, Alcauter Sarael, Reyes-Pérez Paula, Medina-Rivera Alejandra, Vazquez-Guevara Damaris, de María Ugalde-Mejía Lucero, Valadez M Maritza J, Cárdenas-Sáenz Omar, Rodríguez-Leyva Ildefonso, Guerra-Galicia Carlos M, Gandarilla-Martínez Nadia A, Matuk-Pérez Yamil, Morelos-Figaredo Eugenia, Salinas-Barboza Karla, Isais-Millán Sara, Pérez-Torres Teresa, Deras Gaucin Diana C, Ruiz-Contreras Alejandra E, Estrada-Bellmann Ingrid, Rios-Pinto Julia, Cornejo-Olivas Mario, Cosentino Carlos, Torres Ramirez Luis, Mori Nicanor, Mejía-Rojas Koni, Medina Ángel César, Cornejo-Herrera Iván, Ochoa Edward M, Viñuela Ángel, Dieguez Elena, Amorín Ignacio, Lescano Andrés, Mata Ignacio F. Sex differences in the diagnosis latency of Parkinson's disease in Latin America.. Parkinsonism & related disorders. 2025. DOI: 10.1016/j.parkreldis.2025.107344.

Предметные рубрики MeSH

Humans Parkinson Disease Male Female Latin America Middle Aged Aged Sex Characteristics Age of Onset Adult Cohort Studies Aged, 80 and over

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