Deoxynivalenol regulates intestinal and stem cell regeneration via the Hippo pathway and clinical intervention strategies.

This review article examines the molecular pathways through which the environmental contaminant deoxynivalenol (DON) influences the regeneration and renewal of both intestinal tissues and intestinal stem cells via the Hippo Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signaling cascade, while also exploring possible clinical intervention approaches. To begin, the review outlines the prevalent issue of DON contamination and its adverse effects on gastrointestinal health, underscoring the necessity for a comprehensive understanding of its implications. Subsequently, the discussion focuses on the significance of the Hippo YAP/TAZ pathway in preserving the homeostasis of intestinal stem cells and clarifies the mechanisms by which DON perturbs this essential process. In conclusion, the article consolidates potential therapeutic targets and clinical strategies designed to mitigate the intestinal damage caused by DON, thereby providing fresh perspectives on treatment options for gut injuries.