PLGA-lecithin nanocarrier encapsulating curcuma caesia oil in a mucoadhesive gel: efficacy analysis against periodontal infections.

AIM: The study reported development of Curcuma caesia leaf essential oil encapsulated poly(lactic-co-glycolic acid) (PLGA) nanocarrier-embedded gel as a potential strategy to treat periodontal infection.

METHOD: Curcuma caesia oil loaded experimental nanocarriers (CNCs) were developed by nano precipitation method and characterized. In vitro and in vivo efficacy of CNCs loaded gel (CNCsG) was evaluated.

RESULTS

GC/MS analysis revealed Borneol as the major phytoactive constituent. CNCs were spherical, nanosized (51.28 ± 2.1 nm), with -40.5 ± 0.8% mV surface charge, 20.8 ± 0.7% w/w oil loading and 86.4 ± 1.3% encapsulation efficiency. CNCsG was reported with satisfied mucoadhesion (45.66 ± 2.2 dyne/cm2), viscosity (37745 ± 32.7 cps), spreadability (6.5 ± 1.2 gm.cm/sec), sustained ex-vivo release. A faster recovery of infection towards normal was observed in periodontitis rats by CNCsG than Clorni gel. Improved plasma pharmacokinetic profile was reported for CNCsG as compared to standard gel.

CONCLUSION

CNCsG was reported having promising antibacterial potency. In vivo efficacy data would lay foundation for futuristic clinical testing of CNCsG in periodontitis.