Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
Factors associated with drug adherence in psoriasis: a single-center, retrospective, questionnaire-based exploratory study in Bavaria.
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Jalili-Tazeshahri Negahr, Huppertz Gunnar, Kurz Bernadett, von Eichborn Maria Isabel, Berneburg Mark, Maisch Tim, Niebel Dennis
Аннотация
BACKGROUND AND OBJECTIVES: Achieving sustained drug adherence in psoriasis remains challenging despite effective therapies. This exploratory study aims to investigate the care situation and factors associated with drug adherence in patients with moderate-to-severe psoriasis vulgaris (PsO).
PATIENTS AND METHODS: A single-center study was conducted at the University Medical Center Regensburg, Germany, comprising a retrospective analysis of 312 patient records of individuals treated between 01/2023 and 06/2023 and a prospective questionnaire-based cross-sectional survey of 62 patients treated between 10/2023 and 03/2024. Sociodemographic, clinical, and treatment-related variables and quality of life (QoL) were analyzed descriptively and explored using inferential statistics.
RESULTS: Most patients resided outside the urban care center (82.1% retrospective, 81.0% prospective). Approximately three quarters were adherent (75.0% and 72.4%, respectively). Non-adherence was associated with occupational status, medication class, adverse events, and nicotine use. Patient-reported reasons included administrative barriers (43.8%), financial burden, and adverse events (18.8% each). Non-adherent patients tended to report higher disease burden and lower QoL.
CONCLUSIONS: Drug adherence in moderate-to-severe PsO is associated with socioeconomic and therapy-related factors. Targeted patient-centered strategies may help improve long-term adherence, particularly in vulnerable patient groups, optimize overall outcomes, and reduce financial burden on the healthcare system.
PATIENTS AND METHODS: A single-center study was conducted at the University Medical Center Regensburg, Germany, comprising a retrospective analysis of 312 patient records of individuals treated between 01/2023 and 06/2023 and a prospective questionnaire-based cross-sectional survey of 62 patients treated between 10/2023 and 03/2024. Sociodemographic, clinical, and treatment-related variables and quality of life (QoL) were analyzed descriptively and explored using inferential statistics.
RESULTS: Most patients resided outside the urban care center (82.1% retrospective, 81.0% prospective). Approximately three quarters were adherent (75.0% and 72.4%, respectively). Non-adherence was associated with occupational status, medication class, adverse events, and nicotine use. Patient-reported reasons included administrative barriers (43.8%), financial burden, and adverse events (18.8% each). Non-adherent patients tended to report higher disease burden and lower QoL.
CONCLUSIONS: Drug adherence in moderate-to-severe PsO is associated with socioeconomic and therapy-related factors. Targeted patient-centered strategies may help improve long-term adherence, particularly in vulnerable patient groups, optimize overall outcomes, and reduce financial burden on the healthcare system.