Muscle & nerve · 2012
Ocular and generalized myasthenia gravis induced by human acetylcholine receptor γ subunit immunization.
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Wu Xiaorong, Tuzun Erdem, Li Jing, Xiao Tianlin, Saini Shamsher S, Qi Huibin, Allman Windy, Christadoss Premkumar
Аннотация
INTRODUCTION: HLA-DQ8 transgenic mice develop ocular myasthenia gravis (oMG), which then progresses to generalized MG (gMG) when immunized with the human acetylcholine receptor (H-AChR) α subunit. Because the fetal AChR γ subunit is expressed in adult extraocular muscles, we anticipated that γ subunit immunization would generate an immune response to mouse AChR and induce MG in mice.
RESULTS: H-AChR γ subunit immunization in HLA-DQ8 mice induced an autoimmune response to mouse AChR and led to the destruction of AChR in the neuromuscular junction (NMJ) by anti-AChR antibody and complement activation, and it triggered upregulation of AChR gene transcription.
CONCLUSION: Our findings indicate that oMG may be induced by immunity to the AChR γ subunit.
RESULTS: H-AChR γ subunit immunization in HLA-DQ8 mice induced an autoimmune response to mouse AChR and led to the destruction of AChR in the neuromuscular junction (NMJ) by anti-AChR antibody and complement activation, and it triggered upregulation of AChR gene transcription.
CONCLUSION: Our findings indicate that oMG may be induced by immunity to the AChR γ subunit.
Предметные рубрики MeSH
AnimalsAntibodies, Anti-IdiotypicArabidopsis ProteinsCell ProliferationComplement C3Disease Models, AnimalEnzyme-Linked Immunosorbent AssayHLA-DQ AntigensHumansImmunizationIntramolecular TransferasesLymphocyte ActivationMiceMice, TransgenicMuscle StrengthMyasthenia Gravis, Autoimmune, ExperimentalNeuromuscular JunctionOcular Motility DisordersProtein SubunitsReceptors, Nicotinic