Biomarkers in medicine · 2016
Serum sclerostin level might be a potential biomarker for arterial stiffness in prevalent hemodialysis patients.
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Jin Shi, Zhu Mingli, Yan Jiayi, Fang Yan, Lu Renhua, Zhang Weiming, Zhang Qi, Lu Jiayue, Qi Chaojun, Shao Xinghua, Zhang Haifen, Jiang Rong, Ni Zhaohui
Аннотация
AIM: To explore the relationship between circulating sclerostin levels and pulse wave velocity (PWV) in prevalent hemodialysis (HD) patients.
PATIENTS & METHODS: 154 HD patients were enrolled and examined for serum sclerostin level, carotid-femoral pulse wave velocity (cf-PWV), abdominal artery calcification and calcaneus bone marrow density.
RESULTS: Serum sclerostin level was significantly elevated in patients with arterial stiffness. Univariate correlation showed serum sclerostin level significantly correlated with intact parathyroid hormone level, cf-PWV and calcaneus bone marrow density. Multiple linear regression analysis in patients with parathyroid hormone ≤300 pg/ml showed that pulse pressure, logAACs and serum sclerostin level were significant independent factors for cf-PWV.
CONCLUSION: Serum sclerostin level was significantly associated with PWV in prevalent HD patients without hyperparathyroidism.
PATIENTS & METHODS: 154 HD patients were enrolled and examined for serum sclerostin level, carotid-femoral pulse wave velocity (cf-PWV), abdominal artery calcification and calcaneus bone marrow density.
RESULTS: Serum sclerostin level was significantly elevated in patients with arterial stiffness. Univariate correlation showed serum sclerostin level significantly correlated with intact parathyroid hormone level, cf-PWV and calcaneus bone marrow density. Multiple linear regression analysis in patients with parathyroid hormone ≤300 pg/ml showed that pulse pressure, logAACs and serum sclerostin level were significant independent factors for cf-PWV.
CONCLUSION: Serum sclerostin level was significantly associated with PWV in prevalent HD patients without hyperparathyroidism.