Resolution of thrombotic thrombocytopenic purpura serous retinal detachment following rituximab therapy.

PURPOSE: To report a case of bilateral serous retinal detachment occurring early in the course of thrombotic thrombocytopenic purpura (TTP), with a complete and sustained visual and anatomical recovery following rituximab treatment.

METHODS

Clinical and laboratory assessments were performed, supplemented by serial optical coherence tomography imaging. Treatment was pursued with corticotherapy, plasmapheresis and rituximab.

RESULTS

Vision-threatening serous retinal detachments associated with TTP responded favorably to rituximab, leading to a complete retinal reattachment within one week and full visual recovery within one month.

CONCLUSION

Serous retinal detachment should be considered in cases of acute painless visual loss in patients with TTP. Prompt escalation of immunotherapy, particularly rituximab, seems to safeguard excellent visual and anatomical outcomes.