Prefrontal working memory activity slots support sequence memory similar to hippocampal long-term memory position recall.

Prefrontal cortex and medial temporal lobe information processing might not be that different after all. In this issue of Neuron, Whittington et al.1 show that prefrontal cortex working memory slot activity enables sequence memorizing similar to hippocampal long-term memory. Here, this approach is outlined and its implications are discussed.