Correlation between biochemical indicators of blood lipid with cerebral vascular diseases.

OBJECTIVE

The objective of this study was to investigate correlation of the changes in serum levels of cholesterol (chol), lipoprotein (a) (Lpa) and homocysteine (HCY) with incident cerebral infarction and cerebral hemorrhage.

METHODS

Data on a total of 418 patients (318 cerebral infarction events and 100 cerebral hemorrhage cases) were analyzed in this study. Serum chol and HCY levels were tested by means of GPO-PAP. Serum Lpa levels were measured using latex agglutination turbidimetry.

RESULTS

Patients with cerebral infarction showed significantly higher serum Lpa levels and anomaly ratio than those with cerebral hemorrhage (P<0.05), while no significant changes were identified for chol and HCY (P>0.05). Analyses by age indicated substantially increased Lpa concentration among cerebral infarction patients>60 years of age (P<0.05). No statistical significance was observed in other analyses carried out in the study.

CONCLUSION

These results demonstrate that Lpa concentration is clearly correlated with cerebral infarction incidence. Lpa may act as an independent risk factor and could be used as a biomarker for this disease.