Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
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Dixon-Suen Suzanne C, Nagle Christina M, Thrift Aaron P, Pharoah Paul D P, Ewing Ailith, Pearce Celeste Leigh, Zheng Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench Georgia, Fasching Peter A, Beckmann Matthias W, Lambrechts Diether, Vergote Ignace, Lambrechts Sandrina, Van Nieuwenhuysen Els, Rossing Mary Anne, Doherty Jennifer A, Wicklund Kristine G, Chang-Claude Jenny, Jung Audrey Y, Moysich Kirsten B, Odunsi Kunle, Goodman Marc T, Wilkens Lynne R, Thompson Pamela J, Shvetsov Yurii B, Dörk Thilo, Park-Simon Tjoung-Won, Hillemanns Peter, Bogdanova Natalia, Butzow Ralf, Nevanlinna Heli, Pelttari Liisa M, Leminen Arto, Modugno Francesmary, Ness Roberta B, Edwards Robert P, Kelley Joseph L, Heitz Florian, du Bois Andreas, Harter Philipp, Schwaab Ira, Karlan Beth Y, Lester Jenny, Orsulic Sandra, Rimel Bobbie J, Kjær Susanne K, Høgdall Estrid, Jensen Allan, Goode Ellen L, Fridley Brooke L, Cunningham Julie M, Winham Stacey J, Giles Graham G, Bruinsma Fiona, Milne Roger L, Southey Melissa C, Hildebrandt Michelle A T, Wu Xifeng, Lu Karen H, Liang Dong, Levine Douglas A, Bisogna Maria, Schildkraut Joellen M, Berchuck Andrew, Cramer Daniel W, Terry Kathryn L, Bandera Elisa V, Olson Sara H, Salvesen Helga B, Thomsen Liv Cecilie Vestrheim, Kopperud Reidun K, Bjorge Line, Kiemeney Lambertus A, Massuger Leon F A G, Pejovic Tanja, Bruegl Amanda, Cook Linda S, Le Nhu D, Swenerton Kenneth D, Brooks-Wilson Angela, Kelemen Linda E, Lubiński Jan, Huzarski Tomasz, Gronwald Jacek, Menkiszak Janusz, Wentzensen Nicolas, Brinton Louise, Yang Hannah, Lissowska Jolanta, Høgdall Claus K, Lundvall Lene, Song Honglin, Tyrer Jonathan P, Campbell Ian, Eccles Diana, Paul James, Glasspool Rosalind, Siddiqui Nadeem, Whittemore Alice S, Sieh Weiva, McGuire Valerie, Rothstein Joseph H, Narod Steven A, Phelan Catherine, Risch Harvey A, McLaughlin John R, Anton-Culver Hoda, Ziogas Argyrios, Menon Usha, Gayther Simon A, Ramus Susan J, Gentry-Maharaj Aleksandra, Wu Anna H, Pike Malcolm C, Tseng Chiu-Chen, Kupryjanczyk Jolanta, Dansonka-Mieszkowska Agnieszka, Budzilowska Agnieszka, Rzepecka Iwona K, Webb Penelope M, Ovarian Cancer Association Consortium
Аннотация
METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.
RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.
CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.