Revista de neurologia · 1997
[Genetic predisposition to Alzheimer's disease].
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Staufenbiel M, Pombo-Villar E
Аннотация
INTRODUCTION: Alzheimer's disease can present either as an early-onset or senile dementia. Its ethiology is heterogeneous but with common clinical and pathological features.
DEVELOPMENT: Alzheimer's syndrome can occur with familial clustering. Some families with pre-senile dementia have shown three different genes which are associated with the pathological features. These genes carry on several mutations which have an autosomal dominant transmission: each mutation seems to be able to cause the pathological changes. The senile dementias are more common but dominant transmission has not been shown. However, risk genetic factors can play a rol. The epsilon 4 allel for apolipoprotein E has been clearly identified.
CONCLUSIONS: It would be possible to use genetic tests to predict the appearance of presenile dementias but these tests are not available for the more common senile types of Alzheimer's dementia.
DEVELOPMENT: Alzheimer's syndrome can occur with familial clustering. Some families with pre-senile dementia have shown three different genes which are associated with the pathological features. These genes carry on several mutations which have an autosomal dominant transmission: each mutation seems to be able to cause the pathological changes. The senile dementias are more common but dominant transmission has not been shown. However, risk genetic factors can play a rol. The epsilon 4 allel for apolipoprotein E has been clearly identified.
CONCLUSIONS: It would be possible to use genetic tests to predict the appearance of presenile dementias but these tests are not available for the more common senile types of Alzheimer's dementia.