Heart rhythm · 2017
Association of preprocedural cardiac magnetic resonance imaging with outcomes of ventricular tachycardia ablation in patients with idiopathic dilated cardiomyopathy.
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Siontis Konstantinos C, Kim Hyungjin Myra, Sharaf Dabbagh Ghaith, Latchamsetty Rakesh, Stojanovska Jadranka, Jongnarangsin Krit, Morady Fred, Bogun Frank M
Аннотация
BACKGROUND: Knowledge of complex arrhythmogenic substrates can help plan ventricular tachycardia (VT) ablation in patients with idiopathic dilated cardiomyopathy (DCM).
OBJECTIVE: The purpose of this study was to assess whether preprocedural late gadolinium enhancement magnetic resonance imaging (LGE-MRI) can improve ablation outcomes in DCM.
METHODS: Consecutive patients (N = 96) with idiopathic DCM underwent VT ablation with open-irrigated catheters (2006-2016). Before 2012, LGE-MRI was not performed at our institution in patients with implanted devices, but it has been performed routinely in all patients after implementation of a new MRI protocol in 2012. We retrospectively compared acute and long-term outcomes of initial VT ablation procedures in patients with (n = 41) and those without (n = 55) preprocedural LGE-MRI. Procedural outcome was classified as successful if VT was not inducible postablation.
RESULTS: The 2 groups had a similar mean age and ejection fraction, comorbidities, and frequency of epicardial ablation. Preablation LGE-MRI was independently associated with improved procedural success (63% vs 24%) by logistic regression analysis (adjusted odds ratio [OR] 7.86, P <.001). This result was consistent even when patients with nondiagnostic MRIs due to artifact were included in the imaging group (OR 4.87, P = .005). Preablation imaging was also associated with improved survival free of the composite endpoint of VT recurrence, heart transplantation, or death, which was met by 11 (27%) and 33 (60%) patients in the imaging and no imaging groups, respectively, after median 7.6 months of follow-up (unadjusted log-rank P = .02). However, there was no association with long-term outcomes after adjustment for other covariates.
CONCLUSION: Preprocedural imaging with LGE-MRI may be associated with improved outcomes of VT ablation in DCM.
OBJECTIVE: The purpose of this study was to assess whether preprocedural late gadolinium enhancement magnetic resonance imaging (LGE-MRI) can improve ablation outcomes in DCM.
METHODS: Consecutive patients (N = 96) with idiopathic DCM underwent VT ablation with open-irrigated catheters (2006-2016). Before 2012, LGE-MRI was not performed at our institution in patients with implanted devices, but it has been performed routinely in all patients after implementation of a new MRI protocol in 2012. We retrospectively compared acute and long-term outcomes of initial VT ablation procedures in patients with (n = 41) and those without (n = 55) preprocedural LGE-MRI. Procedural outcome was classified as successful if VT was not inducible postablation.
RESULTS: The 2 groups had a similar mean age and ejection fraction, comorbidities, and frequency of epicardial ablation. Preablation LGE-MRI was independently associated with improved procedural success (63% vs 24%) by logistic regression analysis (adjusted odds ratio [OR] 7.86, P <.001). This result was consistent even when patients with nondiagnostic MRIs due to artifact were included in the imaging group (OR 4.87, P = .005). Preablation imaging was also associated with improved survival free of the composite endpoint of VT recurrence, heart transplantation, or death, which was met by 11 (27%) and 33 (60%) patients in the imaging and no imaging groups, respectively, after median 7.6 months of follow-up (unadjusted log-rank P = .02). However, there was no association with long-term outcomes after adjustment for other covariates.
CONCLUSION: Preprocedural imaging with LGE-MRI may be associated with improved outcomes of VT ablation in DCM.