[Analysis and reflection on pharmacological effects and novel formulation technologies of lumbrokinase from Pheretima].

Lumbrokinase, a serine protease complex extracted from Pheretima, possesses specific fibrinolytic activity and is clinically used for thrombolytic therapy in cardiovascular and cerebrovascular diseases. Due to its low bleeding risk profile, novel formulation technologies have significantly enhanced its therapeutic efficacy in acute thrombotic diseases. This study discussed the physicochemical properties, absorption properties, pharmacological effects, formulation strategies, and existing challenges of lumbrokinase, providing a comprehensive analysis for its future application and development.