Journal of investigative and clinical dentistry · 2014
Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial.
Сравнительное исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Pradeep Avani R, Singh Sonender P, Martande Santosh S, Naik Savitha B, N Priyanka, Kalra Nitish, Suke Deepak K
Аннотация
AIM: The aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (LFX) as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis (CP).
METHODS: Sixty-five patients with CP were randomly divided into a test (n = 33, SRP and LFX 500 mg, once daily [o.d.]) and a control group (n = 32, SRP and placebo, o.d.). Plaque index (PI), gingival index (GI), percentage of sites with bleeding on probing (%BoP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 10 days, and 1-, 3-, and 6-month intervals. The percentage of sites positive for Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis, and Tannerella forsythia were recorded at baseline and at 3 and 6 months.
RESULTS: Patients receiving LFX showed statistically-significant improvements in mean PD and CAL. The intergroup difference in PI, GI, and%BoP was not significant at any interval. There was a reduction in the percentage of sites positive for periodontopathic bacteria over the duration of the study in both groups, and a statistically-significant reduction in the number of sites positive for A. actinomycetemcomitans in the LFX group (P < 0.001).
CONCLUSION: Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals.
METHODS: Sixty-five patients with CP were randomly divided into a test (n = 33, SRP and LFX 500 mg, once daily [o.d.]) and a control group (n = 32, SRP and placebo, o.d.). Plaque index (PI), gingival index (GI), percentage of sites with bleeding on probing (%BoP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 10 days, and 1-, 3-, and 6-month intervals. The percentage of sites positive for Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis, and Tannerella forsythia were recorded at baseline and at 3 and 6 months.
RESULTS: Patients receiving LFX showed statistically-significant improvements in mean PD and CAL. The intergroup difference in PI, GI, and%BoP was not significant at any interval. There was a reduction in the percentage of sites positive for periodontopathic bacteria over the duration of the study in both groups, and a statistically-significant reduction in the number of sites positive for A. actinomycetemcomitans in the LFX group (P < 0.001).
CONCLUSION: Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals.
Предметные рубрики MeSH
AdultAggregatibacter actinomycetemcomitansAnti-Bacterial AgentsAnti-Infective Agents, LocalBacterial LoadChlorhexidineChronic PeriodontitisCombined Modality TherapyDental PlaqueDental Plaque IndexDental ScalingDouble-Blind MethodFemaleFollow-Up StudiesHumansLevofloxacinMaleMouthwashesPeriodontal Attachment LossPeriodontal IndexPeriodontal PocketPlacebosPorphyromonas gingivalisRoot PlaningTannerella forsythia