Movement disorders clinical practice · 2024
Gastrointestinal Dysfunction Bears on the Clinical-Biological Profile of Parkinson's Disease.
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Bissacco Jacopo, Bovenzi Roberta, Conti Matteo, Simonetta Clara, Mascioli Davide, Cerroni Rocco, Sancesario Giulia Maria, Grillo Piergiorgio, Pierantozzi Mariangela, Stefani Alessandro, Mercuri Nicola Biagio, Camacho Marta, Schirinzi Tommaso
Аннотация
BACKGROUND: Gastrointestinal dysfunction (GID) accompanies any phase of Parkinson's disease (PD), underlying differential clinical-pathological trajectories.
OBJECTIVE: To investigate associations between GID and peripheral immune or neurodegeneration-related markers in PD.
METHODS: One-hundred-and-fourteen patients (n = 55 de novo, DN; n = 59 middle-advanced, MA) completed the Gastrointestinal Dysfunction Scale for PD (GIDS-PD), and other motor and non-motor scales; paired measurement of amyloid-β42, amyloid-β42β/β40, total-tau, phosphorylated-181-tau, total α-synuclein CSF levels, albumin ratio, and peripheral blood cell count were collected. Group and correlation analyses were performed.
RESULTS: MA patients had greater GID than DN. GIDS-PD scores directly correlated with MDS-UPDRS-III and non-motor scores in both groups, although more in DN. GIDS-PD scores were directly associated with α-synuclein and inversely with lymphocytes only in DN; conversely, they were positively associated with tau proteins and albumin ratio, and negatively with amyloid-β-peptides in both groups.
CONCLUSIONS: The burden of GID increases along the PD course with associated stage-specific clinical-biological patterns.
OBJECTIVE: To investigate associations between GID and peripheral immune or neurodegeneration-related markers in PD.
METHODS: One-hundred-and-fourteen patients (n = 55 de novo, DN; n = 59 middle-advanced, MA) completed the Gastrointestinal Dysfunction Scale for PD (GIDS-PD), and other motor and non-motor scales; paired measurement of amyloid-β42, amyloid-β42β/β40, total-tau, phosphorylated-181-tau, total α-synuclein CSF levels, albumin ratio, and peripheral blood cell count were collected. Group and correlation analyses were performed.
RESULTS: MA patients had greater GID than DN. GIDS-PD scores directly correlated with MDS-UPDRS-III and non-motor scores in both groups, although more in DN. GIDS-PD scores were directly associated with α-synuclein and inversely with lymphocytes only in DN; conversely, they were positively associated with tau proteins and albumin ratio, and negatively with amyloid-β-peptides in both groups.
CONCLUSIONS: The burden of GID increases along the PD course with associated stage-specific clinical-biological patterns.