Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 1998
Clinical study on chronopharmacokinetics of digoxin in patients with congestive heart failure.
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Liu Z, Fang S, Wang L, Zhu T, Yang H, Yu S
Аннотация
Fluorescence polarization immunoassay was used to study the chronopharmacokinetics of digoxin in 10 patients with congestive heart failure (CHF) who also served as self-controls. Our results showed that the serum digoxin concentration reached peak value 1 h after taking digoxin at 7:00 a.m., but the serum digoxin concentration reached the peak value 2 h after taking digoxin at 4:00 p.m. The average serum digoxin concentration area under curve was greater and the best maintainable time of serum concentration within 24 h after taking digoxin at 4 p.m. longer than those at 7:00 a.m. The heart rates were obviously lower and the cardiac function was significantly improved in 4:00 p.m. group.