The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 1996
Narcolepsy secondary to fourth ventricular subependymoma.
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Ma T K, Ang L C, Mamelak M, Kish S J, Young B, Lewis A J
Аннотация
BACKGROUND: Secondary (symptomatic) narcolepsy is rare. We report a subependymoma of the fourth ventricle associated with narcolepsy. The patient was a 50-year old woman with a long history of narcolepsy who died of colonic carcinoma with no cerebral metastasis. She was positive for HLA-DR2. At autopsy there was a tumour dorsal to the fourth ventricle which involved the midbrain tectum and rostral pons. Histologic examination of the tumour confirmed it to be a subependymoma.
METHODS: Review of the previous cases of secondary narcolepsy was made with particular reference to the anatomical location of the lesions.
RESULTS: Most of the lesions were found around the third ventricle and rostral brainstem.
CONCLUSIONS: Knowing the anatomical localization of the pathological changes in secondary narcolepsy could be important in improving our understanding of its pathogenesis.
METHODS: Review of the previous cases of secondary narcolepsy was made with particular reference to the anatomical location of the lesions.
RESULTS: Most of the lesions were found around the third ventricle and rostral brainstem.
CONCLUSIONS: Knowing the anatomical localization of the pathological changes in secondary narcolepsy could be important in improving our understanding of its pathogenesis.