Indian journal of pharmacology · 2008
Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals.
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Malairajan P, Gopalakrishnan Geetha, Narasimhan S, Veni K Jessi Kala
Аннотация
OBJECTIVE: To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites.
MATERIALS AND METHODS: The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o.
RESULTS: A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer.
CONCLUSION: This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.
MATERIALS AND METHODS: The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o.
RESULTS: A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer.
CONCLUSION: This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.