Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2007
The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage.
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Aydinli Bülent, Yildirgan Mehmet Ilhan, Oztürk Gürkan, Atamanalap Sabri Selçuk, Polat Kamil Yalçin, Başoğlu Mahmut, Gündoğdu Cemal, Süleyman Halis, Kiziltunç Ahmet, Gürsan Nesrin, Oren Durkaya
Аннотация
BACKGROUND: To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model.
METHODS: Gastric ulcers were induced by oral ingestion of indomethacin. Thirty rats were used in the study. The rats were divided into 3 groups, and given either SC (n=10) at a dose of 50 mg/kg or omeprazole (n=10), or no treatment (n=10, the control group). In addition to the measurements of ulceration areas, the sum of gastric tissue nitrite (NO2-) and nitrate (NO3-) were evaluated as an indicator of gastric tissue NO level. All the measurements were done at 6th hour of oral administration of indomethacin.
RESULTS: The mean values of ulceration areas were 4.0+/-2.31, 3.0+/-2.00, and 21.4+/-8.43 in the SC, omeprazole and control groups, respectively. The mean values of ulceration areas in the SC-treated group was lower than that of the control group. The contents of NO were 32.2+/-3.05, 24.8+/-3.23 and 21.0+/-0.82 (micromol/g protein) in gastric tissue in indomethacin, SC, omeprazole and control groups, respectively, The content of NO in the SC-treated groups was significantly higher than control group (p<0.001).
CONCLUSION: Sildenafil citrate may have a role in protecting gastric mucosa from the damage caused by indomethacin. This effect may be associated with the increased level of NO in gastric tissue.
METHODS: Gastric ulcers were induced by oral ingestion of indomethacin. Thirty rats were used in the study. The rats were divided into 3 groups, and given either SC (n=10) at a dose of 50 mg/kg or omeprazole (n=10), or no treatment (n=10, the control group). In addition to the measurements of ulceration areas, the sum of gastric tissue nitrite (NO2-) and nitrate (NO3-) were evaluated as an indicator of gastric tissue NO level. All the measurements were done at 6th hour of oral administration of indomethacin.
RESULTS: The mean values of ulceration areas were 4.0+/-2.31, 3.0+/-2.00, and 21.4+/-8.43 in the SC, omeprazole and control groups, respectively. The mean values of ulceration areas in the SC-treated group was lower than that of the control group. The contents of NO were 32.2+/-3.05, 24.8+/-3.23 and 21.0+/-0.82 (micromol/g protein) in gastric tissue in indomethacin, SC, omeprazole and control groups, respectively, The content of NO in the SC-treated groups was significantly higher than control group (p<0.001).
CONCLUSION: Sildenafil citrate may have a role in protecting gastric mucosa from the damage caused by indomethacin. This effect may be associated with the increased level of NO in gastric tissue.