Nihon rinsho. Japanese journal of clinical medicine · 2007
[The role of mucoprotective drugs in a treatment and prevention for NSAID-induced gastric ulcer].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Okuyama Masatsugu, Tominaga Kazunari, Tanigawa Tetsuya, Shiba Masatsugu, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Arakawa Tetsuo
Аннотация
NSAIDs compromise gastroduodenal defense mechanism mediated by inhibiting cyclooxygenase and leading to leukocyte infiltration or neutrophil adherence, and cause gastric ulcers. There are a number of mucoprotective drugs in Japan, and they were often used for NSAIDs-induced ulcer treatment. In vitro or in vivo studies, some mucoprotective drugs have been shown to have anti-inflammatory action due to the inhibition of leukocyte infiltration, production of inflammatory cytokines. However, mucoprotective drugs were given a low priority in "the Japanese guideline for the management of gastric ulcer" edited in 2003. Therefore, mucoprotective drugs should be investigated in terms of effects on NSAIDs-induced gastric ulcer patients because there are a few reliable evidences for the treatment of NSAID-induced gastric ulcer in Japan.