Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2007
[Effect of mucosal protective on the quality of gastric ulcer healing].
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Qian Yun, Si Jian-Min, Wu Jia-Guo, Chen Shu-Jie, Zhu You-Fa, Sun Ke-Ke, Deng Yan-Yong, Chen Kuang, Wang Liang-Jing, Liu Wei-Li
Аннотация
OBJECTIVE: To explore the mucosal protective effect on the quality of gastric ulcer healing.
METHODS: Gastric ulcers were induced in male rats by serosal application of acetic acid. Rats were gavaged for 14 days with saline, omeprazole (OME), teprenone (TEP) and TEP plus OME starting 3 days after ulcer induction. Then the tissues and blood samples were obtained and measured.
RESULT: The lower ulcer index (UI) and increased ulcer inhibition rate were observed in OME and OME+TEP groups. In TEP and OME+TEP groups, restored mucosa thickness increased, cystically dilated glands decreased, microvessels in connective tissue increased, the secretion of mucus, hexosamine, PGE(2), bFGF were enhanced, the expression of EGFR was increased.
CONCLUSION: TEP can improve the quality of gastric ulcer healing, when combined with OME,the effect is more marked.
METHODS: Gastric ulcers were induced in male rats by serosal application of acetic acid. Rats were gavaged for 14 days with saline, omeprazole (OME), teprenone (TEP) and TEP plus OME starting 3 days after ulcer induction. Then the tissues and blood samples were obtained and measured.
RESULT: The lower ulcer index (UI) and increased ulcer inhibition rate were observed in OME and OME+TEP groups. In TEP and OME+TEP groups, restored mucosa thickness increased, cystically dilated glands decreased, microvessels in connective tissue increased, the secretion of mucus, hexosamine, PGE(2), bFGF were enhanced, the expression of EGFR was increased.
CONCLUSION: TEP can improve the quality of gastric ulcer healing, when combined with OME,the effect is more marked.