Journal of cardiovascular medicine (Hagerstown, Md.) · 2026
Physiology-guided percutaneous coronary intervention using drug-coated balloon versus drug-eluting stent: a propensity-matched analysis.
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Galante Domenico, Pollio Benvenuto Ciro, Todisco Simona, Viceré Andrea, Giuliana Chiara, Viccaro Vincenzo, Tarzia Pierpaolo, Aurigemma Cristina, Romagnoli Enrico, Montone RoccoA, Trani Carlo, Burzotta Francesco, Crea Filippo, Leone Antonio Maria
Аннотация
BACKGROUND: Physiology-guided drug eluting stent percutaneous coronary intervention (ph DES-PCI) improves cardiovascular outcomes; however, the clinical benefit of ph drug coated balloon PCI (ph DCB-PCI) remains unclear.
RESULTS: A propensity-matched analysis of 39 patient pairs (ph DCB-PCI versus ph DES-PCI) from the PROPHET-FFR registry was performed. At 13 months, the MACE rate was similar between the groups (5.1 versus 7.6%, P = 0.644), principally driven by target-vessel revascularization (2.6 versus 7.6%, P = 0.305). A single periprocedural myocardial infarction occurred in the ph DCB-PCI group (P = 0.314).
MAJOR FINDINGS: Ph DCB-PCI appears feasible in selected patients, with no apparent signal of worse outcomes compared with ph DES-PCI, supporting a potential role for physiological assessment in stentless revascularization strategies.
RESULTS: A propensity-matched analysis of 39 patient pairs (ph DCB-PCI versus ph DES-PCI) from the PROPHET-FFR registry was performed. At 13 months, the MACE rate was similar between the groups (5.1 versus 7.6%, P = 0.644), principally driven by target-vessel revascularization (2.6 versus 7.6%, P = 0.305). A single periprocedural myocardial infarction occurred in the ph DCB-PCI group (P = 0.314).
MAJOR FINDINGS: Ph DCB-PCI appears feasible in selected patients, with no apparent signal of worse outcomes compared with ph DES-PCI, supporting a potential role for physiological assessment in stentless revascularization strategies.