Cardiology research and practice · 2026
Prognostic Value of Systemic Immune-Inflammation Index (SII) in Hospital Readmission Following Acute Myocardial Infarction: A Four-Year Analysis.
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Borghei Yasaman, Gholami-Chaboki Bahare, Goli Nasibe, Baharvand Fatemeh, Salari Arsalan
Аннотация
BACKGROUND: Acute myocardial infarction (AMI) initiates an inflammatory response essential for cardiac repair. Several novel inflammatory markers have been identified as indicators of systemic inflammation, including the systemic immune-inflammation index (SII). This study aimed to evaluate the relationship between SII levels and readmission rates in AMI patients.
METHODS: This retrospective cohort study analyzed 1147 AMI patients admitted between 2019 and 2021. The optimal SII cutoff was determined as 694.3 × 109/L, categorizing patients into high SII (≥ 694.3) and low SII (< 694.3) groups. The association between SII levels and readmission risk was assessed using a logistic regression model.
RESULTS: Over 4 years, 454 patients were readmitted, with higher readmission rates (34.4%) observed in the high SII group. Statistically significant differences were noted in primary outcomes, with higher SII patients experiencing increased incidence of major adverse cardiovascular events (MACEs) (p < 0.05). The Cox proportional hazards model indicated that individuals with prior CABG had a 40% higher risk of readmission.
CONCLUSION: Although patients with high SII demonstrated higher hospital readmission rates, primarily due to recurrent MI, no statistically significant association was observed.
METHODS: This retrospective cohort study analyzed 1147 AMI patients admitted between 2019 and 2021. The optimal SII cutoff was determined as 694.3 × 109/L, categorizing patients into high SII (≥ 694.3) and low SII (< 694.3) groups. The association between SII levels and readmission risk was assessed using a logistic regression model.
RESULTS: Over 4 years, 454 patients were readmitted, with higher readmission rates (34.4%) observed in the high SII group. Statistically significant differences were noted in primary outcomes, with higher SII patients experiencing increased incidence of major adverse cardiovascular events (MACEs) (p < 0.05). The Cox proportional hazards model indicated that individuals with prior CABG had a 40% higher risk of readmission.
CONCLUSION: Although patients with high SII demonstrated higher hospital readmission rates, primarily due to recurrent MI, no statistically significant association was observed.