Terapevticheskii arkhiv · 2002
[Fromilid (clarithromycin) in eradication patients in patients with duodenal ulcer associated with Helicobacter pylori (comparison of two treatment variations)].
Клиническое исследованиеКонтролируемое клиническое исследованиеСтатьяНазвание и аннотация: Оригинал на русском
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Vasil'ev Iu V, Zvenigorodskaia L A, Kolomiets E V, Firsanova V Iu
Аннотация
AIM: Comparison of two treatment regimens of eradication treatment of duodenal ulcer (DU) associated with Helicobacter pylori based on fromilid (clarithromycin).
MATERIAL AND METHODS: 20 DU patients associated with HP were divided into two groups. 10 patients of group 1 received omeprazol, fromilid and metronidazol and 10 patients of group 2 were given omeprazol, fromilid and furasolidon for 7 days followed by 2-week omeprazol alone. The patients were examined clinically and endoscopically; HP were detected with a fast urease test and polymerase chain reaction before and after the treatment. Control examinations were performed 6 weeks after the medication.
RESULTS: In group 1 duodenal healing was observed in all the 10 patients, HP eradication occurred in 9 of 10 patients by urease test and in 4 patients by PCR, in group 2 in 8 of 10, 10 of 10 and 10 of 10, respectively.
CONCLUSION: Fromilid (clarithromycin) is effective in eradication treatment in combination with fromilid and metronidazol or furazolidon.
MATERIAL AND METHODS: 20 DU patients associated with HP were divided into two groups. 10 patients of group 1 received omeprazol, fromilid and metronidazol and 10 patients of group 2 were given omeprazol, fromilid and furasolidon for 7 days followed by 2-week omeprazol alone. The patients were examined clinically and endoscopically; HP were detected with a fast urease test and polymerase chain reaction before and after the treatment. Control examinations were performed 6 weeks after the medication.
RESULTS: In group 1 duodenal healing was observed in all the 10 patients, HP eradication occurred in 9 of 10 patients by urease test and in 4 patients by PCR, in group 2 in 8 of 10, 10 of 10 and 10 of 10, respectively.
CONCLUSION: Fromilid (clarithromycin) is effective in eradication treatment in combination with fromilid and metronidazol or furazolidon.