Expert review of endocrinology & metabolism · 2025
Anaplastic thyroid carcinoma: interplay of predictive factors, treatment challenges, and survival insights.
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Ullah Asad, Prasad Kavita, Ahmed Asim, Lee Kue Tylor, Yasinzai Abdul Qahar Khan, Iqbal Asif, Sohail Amir Humza, Arif Dauod, Jogezai Sana, Brandi Luis, Karki Nabin Raj, Khan Marjan, Wali Agha, Jain Hritvik, Karim Nagla Abdel
Аннотация
OBJECTIVE: Anaplastic thyroid carcinoma (ATC) is a rare and aggressive thyroid neoplasm. This study is the largest to date and aims to provide the most up-to-date analysis of demographics and clinicopathological factors of ATC.
METHODS: Data for this study were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.
RESULTS: A total of 1,769 cases of ATC were included with a median age at diagnosis was 71 years, and 59% were females. The most common site of metastasis was the lung (40.7%). The majority of patients underwent combination therapy (surgery with adjuvant chemoradiation) (19.2%). The 5-year OS was 7.3% (95% C.I. 6.6-8.0). The 5-year CSS was 11.8% (95% C.I. 10.8-12.8). The highest 5-year survival was observed with combination therapy (surgery with adjuvant chemoradiation) at 20.9%. Multivariable analysis revealed that age >60 years, Asian/Pacific Islander, >2 cm tumor size, and metastatic disease were independent risk factors.
CONCLUSIONS: ATC is an uncommon tumor that mainly affects Caucasian females in their 70s. Older age, Asian/Pacific Islander race, and larger tumor size (>2 cm) were also associated with a worse prognosis. For better comprehension of pathogenesis, prospective clinical trials should include patients from all ethnicities, gender, and genomic analysis of ATC.
METHODS: Data for this study were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.
RESULTS: A total of 1,769 cases of ATC were included with a median age at diagnosis was 71 years, and 59% were females. The most common site of metastasis was the lung (40.7%). The majority of patients underwent combination therapy (surgery with adjuvant chemoradiation) (19.2%). The 5-year OS was 7.3% (95% C.I. 6.6-8.0). The 5-year CSS was 11.8% (95% C.I. 10.8-12.8). The highest 5-year survival was observed with combination therapy (surgery with adjuvant chemoradiation) at 20.9%. Multivariable analysis revealed that age >60 years, Asian/Pacific Islander, >2 cm tumor size, and metastatic disease were independent risk factors.
CONCLUSIONS: ATC is an uncommon tumor that mainly affects Caucasian females in their 70s. Older age, Asian/Pacific Islander race, and larger tumor size (>2 cm) were also associated with a worse prognosis. For better comprehension of pathogenesis, prospective clinical trials should include patients from all ethnicities, gender, and genomic analysis of ATC.