[The side effect and complication of intraarterial phosphorus-32 glass microspheres for patients with advanced hepatoma].

The phosphorus-32 glass microspheres(32P-GMS) is a new radioembolizer for cancer therapy. From March 1994 to April 1995, 24 patients with unresectable hepatocellular carcinoma and 3 patients with cavernous hemangioma received internal radiation treatment of 32P-GMS. The clinical results demonstrated that hepatic arterial instillation of 32P-GMS appeared to be safe and effective for hepatocellular carcinoma. There was no significant bone marrow or renal toxicity or liver to pulmonary bypass. A transient change of liver function and fever occurred in almost all patients. Significant liver toxicity and gastrointestinal tract reaction were seen when radiation dose > 50 Gy or microspheres > 3 g, and then various postoperative complications occurred.