Acute Posterior Multifocal Placoid Pigment Epitheliopathy: Clinical and Iconographical Aspects of Two Cases.

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory disorder of the choriocapillaris and retinal pigment epithelium. We report two atypical cases: one with unilateral involvement complicated by serous retinal detachment requiring corticosteroid therapy; the second with bilateral involvement that resolved spontaneously. These observations underscore the clinical heterogeneity of APMPPE and the pivotal role of multimodal imaging, including optical coherence tomography (OCT) and OCT-angiography (OCT-A), in elucidating its pathophysiology, guiding diagnosis, monitoring disease progression, and tailoring treatment strategies.