EJIFCC · 2025
Role of Inflammatory and Oxidative Stress Biomarkers with Albuminuria: A Cross Sectional Analysis in Type 2 Diabetes Mellitus Patients.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Parchwani Deepak N, Vachhani Uday, Dholariya Sagar, Agravatt Ashishkumar, Singh Ragini, Sonagra Amit
Аннотация
BACKGROUND: Diabetic nephropathy (DN) is a prevalent and severe complication of type 2 diabetes mellitus (T2DM), contributing to kidney disease and cardiovascular risks. Oxidative stress and inflammation play crucial roles in DN pathogenesis. This study investigates the association of inflammatory cytokines, oxidative stress markers, and cortisol with albuminuria in T2DM patients.
METHODS: A cross-sectional study was conducted on 150 T2DM patients categorized into normoalbuminuria, microalbuminuria, and macroalbuminuria groups. Blood samples were analyzed for total antioxidant capacity (T-AOC), pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-8), high-sensitivity C-reactive protein (hsCRP), and cortisol levels. Statistical analyses included ANOVA and logistic regression.
RESULTS: T2DM patients with albuminuria exhibited significantly lower T-AOC (P=0.027) and elevated TNF-α (P=0.006), IL-1 (P<0.001), IL-6 (P<0.001), IL-8 (P<0.001), hsCRP (P<0.001), and cortisol (P<0.001). High tertiles of TNF-α, IL-6, and hsCRP were strongly associated with increased albuminuria risk, particularly in overweight and hypertensive patients.
CONCLUSION: The findings highlight the interplay of oxidative stress, inflammation, and metabolic dysregulation in DN progression. Elevated inflammatory markers and cortisol levels correlate with albuminuria severity, emphasizing their potential as biomarkers for early DN detection. Targeting inflammatory pathways may offer therapeutic strategies to mitigate DN progression in T2DM patients.
METHODS: A cross-sectional study was conducted on 150 T2DM patients categorized into normoalbuminuria, microalbuminuria, and macroalbuminuria groups. Blood samples were analyzed for total antioxidant capacity (T-AOC), pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-8), high-sensitivity C-reactive protein (hsCRP), and cortisol levels. Statistical analyses included ANOVA and logistic regression.
RESULTS: T2DM patients with albuminuria exhibited significantly lower T-AOC (P=0.027) and elevated TNF-α (P=0.006), IL-1 (P<0.001), IL-6 (P<0.001), IL-8 (P<0.001), hsCRP (P<0.001), and cortisol (P<0.001). High tertiles of TNF-α, IL-6, and hsCRP were strongly associated with increased albuminuria risk, particularly in overweight and hypertensive patients.
CONCLUSION: The findings highlight the interplay of oxidative stress, inflammation, and metabolic dysregulation in DN progression. Elevated inflammatory markers and cortisol levels correlate with albuminuria severity, emphasizing their potential as biomarkers for early DN detection. Targeting inflammatory pathways may offer therapeutic strategies to mitigate DN progression in T2DM patients.