Clinical endocrinology · 2025
Environmental Endocrine-Disrupting Chemicals, Pancreatic β-Cells, and Type 2 Diabetes Mellitus.
СтатьяОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhao Yan-Li, Ou Yang
Аннотация
OBJECTIVE: To clarify the link between environmental pollution and diabetes risk by focusing on pancreatic β-cells as key targets of environmental insults, with emphasis on the role of endocrine-disrupting chemicals (EDCs) in pancreatic dysfunction and diabetes pathogenesis.
METHODS: This narrative review synthesises recent research on EDCs, focusing on their effects on β-cells. The literature search included studies in English on EDCs, diabetes, and β-cell function, utilising Boolean operators to refine the search.
RESULTS: EDCs impair β-cell function through mechanisms such as oxidative stress, mitochondrial damage, and epigenetic changes. These pollutants disrupt insulin synthesis, secretion, and β-cell survival, which is distinct from their general metabolic effects. Additionally, EDCs may interact synergistically with traditional diabetes risk factors, such as high-fat diets, amplifying the risk of diabetes.
CONCLUSION: Environmental pollutants play a significant role in β-cell dysfunction and diabetes, offering new directions for research and prevention.
METHODS: This narrative review synthesises recent research on EDCs, focusing on their effects on β-cells. The literature search included studies in English on EDCs, diabetes, and β-cell function, utilising Boolean operators to refine the search.
RESULTS: EDCs impair β-cell function through mechanisms such as oxidative stress, mitochondrial damage, and epigenetic changes. These pollutants disrupt insulin synthesis, secretion, and β-cell survival, which is distinct from their general metabolic effects. Additionally, EDCs may interact synergistically with traditional diabetes risk factors, such as high-fat diets, amplifying the risk of diabetes.
CONCLUSION: Environmental pollutants play a significant role in β-cell dysfunction and diabetes, offering new directions for research and prevention.