Surgery today · 2025
Clinical relevance of the red blood cell distribution width measured preoperatively as a prognostic marker in patients with distal cholangiocarcinoma undergoing pancreaticoduodenectomy.
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Niki Maiko, Mori Shozo, Miyashita Shotaro, Hayakawa Tomoaki, Tanaka Genki, Shimizu Takayuki, Yamaguchi Takamune, Park Kyung-Hwa, Shiraki Takayuki, Matsumoto Takatsugu, Aoki Taku
Аннотация
PURPOSE: The clinical relevance of the red blood cell distribution width (RDW) in patients with distal cholangiocarcinoma (DCC) undergoing pancreaticoduodenectomy (PD) has not been clearly investigated.
METHODS: The relationship between the preoperatively measured RDW and prognosis for the recurrence/survival was evaluated in patients with DCC undergoing PD. A subgroup analysis was also performed in patients with pathological stage I DCC.
RESULTS: A total of 77 patients were included in the analysis. The cutoff value of the preoperatively measured RDW was set at 14%, and the normal reference range at our center was ≤ 14%. The patient group with an RDW > 14% (n = 30) had a significantly lower mean serum albumin level, higher mean serum carbohydrate antigen 19-9 level, and a higher proportion of cases with pathological lymphatic invasion and showed a significantly worse overall survival than the patient group with an RDW ≤ 14% (n = 47). Similar findings were noted in both the overall study population and patients with pathological stage I disease. Multivariate analysis identified an RDW > 14% and pathological lymph node metastasis as independent risk factors for a poor postoperative survival.
CONCLUSION: The preoperatively measured RDW is a promising prognostic predictor in patients with DCC undergoing PD.
METHODS: The relationship between the preoperatively measured RDW and prognosis for the recurrence/survival was evaluated in patients with DCC undergoing PD. A subgroup analysis was also performed in patients with pathological stage I DCC.
RESULTS: A total of 77 patients were included in the analysis. The cutoff value of the preoperatively measured RDW was set at 14%, and the normal reference range at our center was ≤ 14%. The patient group with an RDW > 14% (n = 30) had a significantly lower mean serum albumin level, higher mean serum carbohydrate antigen 19-9 level, and a higher proportion of cases with pathological lymphatic invasion and showed a significantly worse overall survival than the patient group with an RDW ≤ 14% (n = 47). Similar findings were noted in both the overall study population and patients with pathological stage I disease. Multivariate analysis identified an RDW > 14% and pathological lymph node metastasis as independent risk factors for a poor postoperative survival.
CONCLUSION: The preoperatively measured RDW is a promising prognostic predictor in patients with DCC undergoing PD.